TABLE 3.

Effect of SCP-2 overexpression and cholesterol-rich diet on biliary concentrations of total cholesterol, phospholipids, and bile acids

	WT		SCP-2 Overexpressor
Lipid	Control	Cholesterol	Control	Cholesterol
	Female Mice
Total cholesterol	1.6 ± 0.2	6.5 ± 0.2*	1.6 ± 0.3	4.4 ± 0.2**,@
Phospholipid	17.2 ± 0.9	30 ± 1*	16.0 ± 0.8	25 ± 6
Bile acid	184 ± 16	288 ± 15*	310 ± 13*	294 ± 15
	Male Mice
Total cholesterol	1.6 ± 0.2	3.4 ± 0.3*	1.2 ± 0.1	4.7 ± 0.2**,@
Phospholipid	18.1 ± 0.8	14.5 ± 0.6*	17.3 ± 0.8	22 ± 1**,@
Bile acid	293 ± 15	315 ± 16	270 ± 7	298 ± 11

Concentrations of total cholesterol (mmol/L), phospholipids (mmol/L), and bile acids (mmol/L) were determined as described in Materials and Methods. Values represent means ± SE, n = 3–8. * Indicates P < 0.002 compared with WT mice on the control diet. ** Indicates P < 0.003 compared with SCP-2-overexpressing mice on the control diet. The “at” symbol (@) indicates P < 0.007 compared with mice on the cholesterol-rich diet.