TABLE 4.
Total bile acid content (nmol) in liver, serum, and gall bladder bile in control and cholesterol-fed SCP-2-overexpressing mice
| WT |
SCP-2 Overexpressor |
|||
|---|---|---|---|---|
| Source | Control | Cholesterol | Control | Cholesterol |
| Female Mice | ||||
| Liver | 52 ± 6 | 145 ± 20* | 52 ± 11 | 42 ± 6@ |
| Serum | 4.4 ± 0.7 | 4.4 ± 0.9 | 8 ± 1* | 5 ± 1 |
| Gall bladder | 3,922 ± 347 | 5,770 ± 309* | 6,209 ± 267* | 5,888 ± 136 |
| Total | 3,967 ± 340 | 5,881 ± 291* | 6,243 ± 253* | 5,915 ± 129 |
| Male Mice | ||||
| Liver | 278 ± 28 | 430 ± 34* | 482 ± 54* | 267 ± 14**,@ |
| Serum | 4.6 ± 0.5 | 5.0 ± 0.8 | 8 ± 1* | 3.9 ± 0.4** |
| Gall bladder | 5,860 ± 300 | 6,300 ± 320 | 5,400 ± 147 | 5,967 ± 217 |
| Total | 6,085 ± 305 | 6,511 ± 311 | 5,679 ± 207 | 6,147 ± 198 |
Levels (nmol) of total bile acid in liver, serum, and gall bladder were determined as described in Materials and Methods. Values represent means ± SE, n = 3–8. (*) indicates P < 0.03 compared with WT mice on the control diet. ** Indicates P < 0.002 compared with SCP-2-overexpressing mice on the control diet. The “at” symbol (@) indicates P < 0.003 compared with mice on the cholesterol-rich diet.