TABLE 1.

Clinical characteristics by apoC-I genotype across ethnicity

	African Americans				Caucasians
Characteristics	H1/H1 (n = 103)	H1/H2 (n = 88)	H2/H2 (n = 20)	P	H1/H1 (n = 191)	H1/H2 (n = 101)	H2/H2 (n = 14)	P
Total cholesterol (mg/dl)	209 ± 47	190 ± 41a	172 ± 39a	<0.001	193 ± 39	200 ± 40	191 ± 53	NS
LDL cholesterol (mg/dl)	136 ± 41	117 ± 40a	101 ± 41a	<0.001	120 ± 32	122 ± 36	116 ± 43	NS
HDL cholesterol (mg/dl)	49 ± 17	50 ± 19	47 ± 16	NS	40 ± 12	41 ± 12	39 ± 14	NS
Triglyceride (mg/dl)	117 ± 47	116 ± 55	122 ± 72	NS	170 ± 90	196 ± 117	174 ± 74	NS
ApoA-I (mg/dl)	132 ± 31	129 ± 29	126 ± 27	NS	121 ± 22	124 ± 24	113 ± 20	NS
ApoB (mg/dl)	143 ± 42	126 ± 37a	113 ± 40a	0.001	133 ± 32	138 ± 40	130 ± 41	NS
Glucose (mg/dl)	122 ± 56	113 ± 42	146 ± 81b	0.048	128 ± 61	138 ± 69	105 ± 23	NS
Insulin (μU/ml)	22 ± 27	18 ± 20	30 ± 26b	0.035	26 ± 35	30 ± 48	20 ± 17	NS
HOMA-IR	2.6 ± 2.4	2.4 ± 2.5	4.2 ± 3.3a,b	0.011	3.5 ± 4.3	3.5 ± 4.8	2.6 ± 2.1	NS

Data are means ± SD. Apo, apolipoprotein; HOMA-IR, homeostasis model assessment–insulin resistance; NS, not significant. P values were calculated using one-way ANOVA and post hoc analyses were performed with the Tukey-HSD test for two independent samples. Values for triglycerides, insulin and HOMA-IR were logarithmically transformed before analyses. Nontransformed values are shown in the table.

^aP < 0.05 compared with H1 homozygote subjects.

^bP < 0.05 compared with H1/H2 heterozygote subjects.