TABLE 2.

Clinical characteristics by CAD across ApoC-I genotype in Caucasians and African Americans

	Without CAD			With CAD
	H1/H1	H1/H2, H2/H2	P	H1/H1	H1/H2, H2/H2	P
African Americans	n = 59	n = 55		n = 41	n = 50
Total cholesterol (mg/dl)	206 ± 41	173 ± 38	<0.001	215 ± 56	200 ± 40b	NS
LDL cholesterol (mg/dl)	134 ± 35	102 ± 37	<0.001	141 ± 49	126 ± 39b	NS
HDL cholesterol (mg/dl)	50 ± 16	51 ± 19	NS	48 ± 17	48 ± 17	NS
Triglyceride (mg/dl)	109 ± 44	101 ± 39	NS	128 ± 51a	130 ± 69b	NS
ApoA-I (mg/dl)	136 ± 32	131 ± 30	NS	127 ± 27	125 ± 27	NS
ApoB (mg/dl)	138 ± 37	112 ± 34	<0.001	152 ± 48	134 ± 36b	NS
Glucose (mg/dl)	112 ± 36	111 ± 43	NS	136 ± 75a	124 ± 47	NS
Insulin (μU/ml)	20 ± 31	18 ± 18	NS	25 ± 23	24 ± 26	NS
HOMA-IR	2.1 ± 1.5	2.4 ± 2.3	NS	3.4 ± 3.2a	3.1 ± 3.1	NS
Caucasians	n = 76	n = 52		n = 110	n = 60
Total cholesterol (mg/dl)	187 ± 39	195 ± 41	NS	198 ± 40	203 ± 41	NS
LDL cholesterol (mg/dl)	114 ± 29	120 ± 34	NS	126 ± 35a	125 ± 39	NS
HDL cholesterol (mg/dl)	42 ± 14	43 ± 12	NS	39 ± 11a	40 ± 12	NS
Triglyceride (mg/dl)	157 ± 93	168 ± 90	NS	179 ± 88a	218 ± 127b	0.038
ApoA-I (mg/dl)	124 ± 24	125 ± 22	NS	119 ± 20	122 ± 26	NS
ApoB (mg/dl)	124 ± 29	136 ± 46	NS	141 ± 34a	139 ± 35	NS
Glucose (mg/dl)	118 ± 64	130 ± 58	NS	134 ± 59	137 ± 74	NS
Insulin (μU/ml)	22 ± 27	34 ± 60	NS	29 ± 40	22 ± 19	NS
HOMA-IR	2.9 ± 3.5	3.2 ± 5.1	NS	3.8 ± 4.7	3.3 ± 3.7	NS

Apo, apolipoprotein; CAD, coronary artery disease; HOMA-IR, homeostasis model assessment–insulin resistance. Data are means ± SD. P values calculated using Student's t-test. Values for triglycerides, insulin and HOMA-IR were logarithmically transformed before analyses. Nontransformed values are shown.

^aP < 0.05 compared with H1/H1 across CAD status.

^bP < 0.05 compared with H1/H2, H2/H2 across CAD status.