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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Front Biosci. 2009 Jan 1;14:2829–2844. doi: 10.2741/3416

Figure 5. Functional FxrEs and Lrh-1 binding sites in the proximal promoter of murine Ost alpha and Ost beta, and functional FXREs in the proximal promoter of human OST alpha and OST beta.

Figure 5

After heterodimerization with RXR alpha, FXR binds to the FXRE cis-acting element with an idealized sequence of an inverted hexameric nucleotide repeat consisting of minor variants of two AGGTCA half-sites separated by one nucleotide (IR-1) (100–102). LRH-1 binds to a consensus sequence of YCAAGGYCR where Y is any pyridine and R is any purine (103). A: position of functional FxrEs and Lrh-1 binding sites in the promoters of murine Ost alpha and Ost beta relative to putative transcription start sites and sequence comparison of the functional cis-acting elements to optimal binding sequences (62). B: location of human OST alpha and OST beta functional FXREs with sequence comparison to an idealized binding sequence (64). Conservation of the murine Lrh-1 binding sites in the promoters of their human counterparts has been indicated although the exact position and sequence of the cis-acting elements have not been published (62). Therefore, OST alpha and OST beta are assumed to be negatively regulated in a similar fashion as their murine orthologues.