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. Author manuscript; available in PMC: 2009 Jun 9.
Published in final edited form as: Nature. 2008 Oct 23;455(7216):1069–1075. doi: 10.1038/nature07423

Figure 6. Significantly mutated pathways in lung adenocarcinomas.

Figure 6

Genetic alterations in lung adenocarcinoma frequently occur in genes of the MAPK signalling, p53 signalling, Wnt signalling, cell cycle and mTOR pathways. Oncoproteins are indicated in pink to red and tumour suppressor proteins are shown in light to dark blue. The darkness of the colours is positively correlated to the percentage of tumours with genetic alterations. Frequency of genetic alterations for each of these pathway members in 188 tumours is indicated. Genes (EGFR, FGFR1, FGFR4, KDR, EPHA3, KRAS, NRAS, MDM2 and CDK6) lying in regions of focal amplification were analysed for the percentage of samples with copy number amplification. Samples with greater than 2.5 and fewer than 1.5 DNA copies were considered as amplified and deleted, respectively. Selected components of each pathway are shown in the figure.