Table 4. Overall survival and disease-free survival: univariate analysis.
|
DFS
|
OS
|
|||
|---|---|---|---|---|
| Variables | OR (95% CI) | P value | OR (95% CI) | P value |
| Age | — | 0.25 | — | 0.34 |
| ECOG PS (0 vs 1) | — | 0.31 | — | 0.42 |
| Sex | — | 0.53 | — | 0.56 |
| Poorly differentiated tumour | 2.17 (1.04–4.61) | 0.04 | 2.32 (1.12–4.81) | 0.031 |
| T1,T2 vs T3,T4 | — | 0.33 | — | 0.20 |
| Lymph node metastasis | 2.94 (1.44–6.13) | 0.003 | 2.16 (1.11–4.18) | 0.02 |
| Adjuvant treatment | — | 0.35 | — | 0.21 |
| CXCR7T Low (n=29)a | 0 | 0 | ||
| CXCR7T high (n=42) | 1.51 (0.80–2.87) | 0.20 | 1.81 (0.91–3.60) | 0.12 |
| CXCR4T low (n=32)a | 1 | 1 | ||
| CXCR4T high (n=39) | 2.12 (0.98–3.82) | 0.067 | 5.55 (1.92–12.31) | 0.0006 |
| HIF-1αT low (n=26)a | 1 | 1 | ||
| HIF-1αT high (n=35) | 1.11 (0.61–2.02) | 0.72 | 1.54 (0.82–2.94) | 0.18 |
DFS=disease-free survival; OS=overall survival; ECOG PS=Eastern Cooperative Oncology Group performance status; CXCR7T=CXCR7 expression in the tumour; CXCR4T=CXCR4 expression in the tumour; HIF-1α=hypoxia-inducible factor-1α; HIF-1αT=HIF-1α expression in the tumour.
a
The analysis of EI score as a continuous variable did not modify the statistical results.