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. 2009 Apr 7;100(9):1434–1437. doi: 10.1038/sj.bjc.6605028

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Copyright © 2009 Cancer Research UK

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Representative immunohistochemical staining of all respiratory chain enzyme complexes and porin of an oncocytic thyroid adenoma. (A) Positive staining for complex I subunit NDUFS4 in normal thyroid tissue (upper part) and immunonegative staining in oncocytic tumour tissue (lower part). (B–E) Increased expression of respiratory chain complex II subunit 70 kDa (B), complex III subunit core 2 (C), complex IV subunit I (D) and complex V subunit-α (E) in oncocytic tumour compared with adjacent normal tissue. (F) Immunohistochemical staining of porin reveals the characteristic upregulation of mitochondria in oncocytic tumour cells compared with normal thyroid tissue.