Table 3.

The characterization of the lipophilicity and SOD-like activity of chloride salts of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. R_f values refer to those calculated using plastic-backed TLC plates (R_f(Plastic)).

Porphyrin	Rf	log POW (determined)a	log POW (predicted)	log kcat
MnTM-2-PyP	0.03		−7.40c	7.79
MnTE-2-PyP	0.06		−6.43c	7.76
MnTnPr-2-PyP	0.11		−5.47c	7.38
MnTnBut-2-PyP	0.19	−4.64		7.25
MnTnHex-2-PyP	0.38	−2.29		7.48
MnTnHep-2-PyP	0.46	−1.63		7.65
MnTnOct-2-PyP	0.49	−0.77		7.71
MnTM-3-PyP	0.05		−6.49d	6.61
MnTE-3-PyP	0.10		−5.41d	6.83
MnTnPr-3-PyP	0.22	−4.53		6.85
MnTnBut-3-PyP	0.40	−3.56		6.74
MnTnHex-3-PyP	0.55	−1.60		6.72

^alog P_BW was determined experimentally using equation (1) and was converted to P_OW using equation (2);

^bconditions: 0.05 M phosphate buffer, 0.1 mM EDTA, pH 7.8, 40 μM xanthine, ~ 2nM xanthine oxidase, 10 μM cytochrome c. The rate of cytchrome c reduction by O₂^·−, k_{cyt c} = 2.6 x 10⁵ M⁻¹ cm⁻¹ is used for calculation of k_cat [44]. The estimated errors are within ±10 %.

^cCalculated according to eq. (5).

^dCalculated according to eq. (6).