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. 2008 Dec;9(8):571–585. doi: 10.2174/138920208786847962

Table 2.

Genes Affected by CNTs Treatment (*Up-Regulation)

Particles Gene Pathway System Author
MWCNTs IL-10
IL-6
NQO1
Cytokine signaling
Electrophile response
Mice (C57BL/6) Mitchell et al. [32]
SWCNTs AP1
NFk-B
HLA-DR
CD80
CD40
Redox-sensitive transcription factor
Macrophage antigen-presenting function
Mice (ICR) Chou et al. [63]
SWCNTs NFk-B Cell death and inflammatory response Human keratinocytes (HaCaT) Manna et al. [16]
SWCNTs p16*
bax
p57
hrk
cdc42
cdc37
cdk2
cdk4
cdk6
cyclinD3
mad2
jak1
ttk
pcdha9
erk
p16*
baxhrk
bak1
p57
FGFR2
TGF beta receptor
TNFAIP2
Cell cycle
Signal transduction
Apoptosis
Human embryo kidney cells (HEK293) Chui et al. [17]
SWCNTs HMO1
HMO2
ERCC4
TP53
Caspase8
ATM
GADD45A
Anti-oxidative, anti-inflammatory functions
Protection from DNA damage
Apoptosis
Cell cycle
Induced under genotoxic effect
Human BJ Forskin cells Sarkar et al. [69]