Table 3.

Relations between age and brain volumes

		Age alone					Age with covariates
Structure	Vol. (mean ± SD)	r	t	p	B	SE	t	p	B	SE
Gray matter	483.75 ± 66.03	-0.12	-1.44	0.1509	-1.34	0.92	-2.13	0.0352	-1.44	0.68
White matter	373.13 ± 68.99	-0.34	-4.23	<0.0001	-3.87	0.92	-5.01	<0.0001	-3.69	0.74
Parenchyma	856.88 ± 99.36	-0.32	-3.92	<0.0001	-5.21	1.33	-7.18	<0.0001	-5.13	0.72
Ventricular CSF	32.04 ± 15.07	0.39	4.93	<0.0001	0.97	0.20	5.24	<0.0001	0.95	0.18
Nonventricular CSF	240.35 ± 63.00	0.37	4.71	<0.0001	3.89	0.83	5.63	<0.0001	3.83	0.68
Lesions (log-transformed)	0.52 ± 0.34	0.45	5.97	<0.0001	0.04	<0.01	6.00	<0.0001	0.03	<0.01
Left caudate	3.56 ± 0.64	-0.24	-2.89	0.0045	-0.03	0.01	-3.02	0.0030	-0.03	0.01
Right caudate	3.82 ± 0.64	-0.19	-2.26	0.0254	-0.02	0.01	-2.58	0.0112	-0.02	0.01
Left putamen	3.56 ± 0.62	-0.37	-4.66	<0.0001	-0.04	0.01	-5.18	<0.0001	-0.04	0.01
Right putamen	3.58 ± 0.67	-0.22	-2.57	0.0112	-0.02	0.01	-3.01	0.0031	-0.03	0.01
Left hippocampus	2.92 ± 0.45	-0.27	-2.48	0.0151	-0.02	0.01	-1.98	0.0510	-0.02	0.01
Right hippocampus	3.09 ± 0.44	-0.36	-3.44	0.0009	-0.03	0.01	-3.11	0.0026	-0.02	0.01

SD=standard deviation; CSF=cerebrospinal fluid; SE=standard error.