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. Author manuscript; available in PMC: 2009 Jun 9.
Published in final edited form as: Proteins. 2008 Jul;72(1):197–208. doi: 10.1002/prot.21908

Figure 5. FKBP45 from Bombyx mori may possess an overlapping active site for both FK506 and RNA.

Figure 5

Identification of the potential active site for FK506 (A) and stem-loop RNA (B) within Bombyx mori FKBP45 indicates that the protein may associate with the drug and RNA in the same region. The characteristic FK506- and rapamycin-binding domain is outlined in white brackets. These simulations also suggest that additional domains surrounding the FKBP drug binding pocket may reduce the protein’s affinity for FK506 and/or create novel sites for drug interactions.