TABLE 1.

Schemata for voting and grading the evidence in the literature

Voting options for the Consensus Committee
A	Agree strongly
B	Agree with minor reservation
C	Agree with major reservation
D	Disagree with minor reservation
E	Disagree with major reservation
F	Disagree strongly
Levels of evidence using the GRADE approach
High	Additional research is unlikely to change the Committee’s confidence in the estimate of the effect
Moderate	Additional research is likely to add important information thereby impacting the Committee’s confidence in the estimate of the effect. In turn, this may lead to a change in the estimate of the effect
Low	Additional research is likely to impact both the Committee’s confidence in the estimate of the effect and change their estimate of the effect
Very Low	Any estimate of the effect is uncertain

GRADE Grading of Recommendations, Assessment, Development and Evaluation