Table 5.
Fully adjusted* hazard ratios and 95% confidence intervals for future provoked venous thromboembolism according to baseline levels of lipid biomarkers, stratified according to hormone therapy use.
| Fully-Adjusted Hazard Ratio (95% CI)* |
||||
|---|---|---|---|---|
| Lipid Biomarker Tertile | 1 | 2 | 3 | P-value |
| Total cholesterol (range, mg/dl) | <194 | 194–225 | >225 | |
| Users | ||||
| Provoked, N | 25 | 24 | 36 | |
| Hazard ratio (95% CI) | 1.0 | 0.82 (0.47–1.43) | 1.11 (0.67–1.86) | 0.57 |
| Non-users | ||||
| Provoked, N | 32 | 33 | 44 | |
| Hazard ratio (95% CI) | 1.0 | 0.98(0.60–01.61) | 1.08 (0.67–1.73) | 0.74 |
| Test for interaction | 0.76 | |||
|
| ||||
| Low-density lipoprotein cholesterol (range, mg/dl) | <107.9 | 107.9–135.6 | >135.6 | |
| Users | ||||
| Provoked, N | 22 | 37 | 26 | |
| Hazard ratio (95% CI) | 1.0 | 1.61 (0.95–2.73) | 1.25 (0.71–2.22) | 0.51 |
| Non-users | ||||
| Provoked, N | 37 | 21 | 51 | |
| Hazard ratio (95% CI) | 1.0 | 0.41 (0.23–0.71) | 0.81 (0.52–1.26) | 0.68 |
| Test for interaction | 0.32 | |||
|
| ||||
| High-density lipoprotein cholesterol (range, mg/dl) | <46.2 | 46.2–58.4 | >58.4 | |
| Users | ||||
| Provoked, N | 22 | 33 | 30 | |
| Hazard ratio (95% CI) | 1.0 | 1.31 (0.76–2.26) | 1.02 (0.57–1.83) | 0.92 |
| Non-users | ||||
| Provoked, N | 48 | 31 | 30 | |
| Hazard ratio (95% CI) | 1.0 | 0.88 (0.55–1.40) | 1.16 (0.71–1.90) | 0.59 |
| Test for interaction | 0.33 | |||
|
| ||||
| Apolipoprotein A–I (range, mg/dl) | <138.1 | 138.1–160.8 | >160.8 | |
| Users | ||||
| Provoked, N | 16 | 27 | 41 | |
| Hazard ratio (95% CI) | 1.0 | 1.05 (0.56–1.95) | 0.99 (0.54–1.79) | 0.91 |
| Non-users | ||||
| Provoked, N | 49 | 40 | 18 | |
| Hazard ratio (95% CI) | 1.0 | 1.11 (0.72–1.70) | 0.89 (0.50–1.57) | 0.80 |
| Test for interaction | 0.96 | |||
|
| ||||
| Apolipoproteins B100 (range, mg/dl) | <89.6 | 89.6–114.1 | >114.1 | |
| Users | ||||
| Provoked, N | 18 | 32 | 34 | |
| Hazard ratio (95% CI) | 1.0 | 1.39 (0.78–2.49) | 1.35 (0.75–2.41) | 0.40 |
| Non-users | ||||
| Provoked, N | 32 | 33 | 42 | |
| Hazard ratio (95% CI) | 1.0 | 0.79 (0.48–1.31) | 0.87 (0.53–1.41) | 0.66 |
| Test for interaction | 0.20 | |||
|
| ||||
| Triglycerides (range, mg/dl) | <95.0 | 95.0–153.0 | >153.0 | |
| Users | ||||
| Provoked, N | 24 | 26 | 35 | |
| Hazard ratio (95% CI) | 1.0 | 0.67 (0.38–1.17) | 0.70 (0.41–1.19) | 0.34 |
| Non-users | ||||
| Provoked, N | 34 | 32 | 43 | |
| Hazard ratio (95% CI) | 1.0 | 0.94 (0.57–1.55) | 1.25 (0.77–2.02) | 0.28 |
| Test for interaction | 0.32 | |||
*
All hazard ratios and 95% confidence intervals are adjusted for age, body mass index (kg/m2), current smoking, and randomized treatment assignment.