Table 4.
Comparison of P Values From the Linkage, FBAT, and Case-Control Association Analyses Using 2 Definitions of Affection Statusa
|
P Value |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Single-Point Analysis |
Multipoint Analysis |
FBAT Analysis |
Case-Control Analysis |
|||||||
| Locus | SNP | Distance, cM | Broad | Narrow | Broad | Narrow | Broad | Narrow | Broad | Narrow |
| 3q26.1 | rs1899169 | 168.1 | .2 | .4 | .07 | .2 | .89 | .9 | .00008 | .000074 |
| 7p22.2 | rs798485 | 6.3 | .00002 | .0002 | .003 | .002 | .06 | .06 | .6057 | .6137 |
| 7p21.3 | rs719423 | 13.6 | .00013 | .00002 | .005 | .01 | .7 | .6 | .0942 | .0994 |
| 7q21.3 | rs961262 | 105.8 | .4 | .3 | .14 | .2 | .84 | .98 | .0008 | .0007 |
| 7q31.1 | rs43077 | 120.6 | .12 | .06 | .4 | .4 | .04 | .05 | .0014 | .0019 |
| 8p21.3 | rs4427168 | 38.3 | .012 | .013 | .0002 | .0012 | .0002 | .0002 | .1826 | .1815 |
| 16q13 | rs735144 | 72.7 | .0003 | .00003 | .008 | .004 | .05 | .06 | .2473 | .2976 |
| 16q21 | rs1482258 | 76.9 | .00005 | .00001 | .007 | .002 | .5 | .9 | .2551 | .2514 |
| 19q13.32 | rs2341000 | 75.8 | .0004 | .012 | .0003 | .0008 | .2 | .5 | .7216 | .7629 |
| 20q13.33 | rs1381100 | 101.9 | .9 | >.99 | .7 | .9 | .2 | .1 | .0003 | .0002 |
| 22q11.21 | rs174345 | 3.6 | .3 | .13 | .5 | .5 | .00006 | .0002 | .9747 | .9362 |
| 22q12.3 | rs762883 | 36.9 | .6 | .6 | .9 | .9 | .4 | .9 | .000065 | .000084 |
Abbreviations: FBAT, family-based association test; SNP, single-nucleotide polymorphism.
a
Broad definition includes definite, probable, and possible Alzheimer disease (AD); narrow definition, definite and probable AD.