Table 5.
Examination of Several Previously Identified Candidate Genes
| FBAT Analysis |
Case-Control Analysis |
|||||
|---|---|---|---|---|---|---|
| Genea | SNP | Location | Z Score | P Value | χ2 Test | P Value |
| MTHFR | rs6685318 | 1p36.22 | 0.422 | .67 | 1.988 | .16 |
| rs6671723 | 1.538 | .12 | 1.364 | .24 | ||
| NCSTN | rs10594 | 1q23.2 | −0.767 | .44 | 2.293 | .13 |
| rs570901 | 1q23.3 | −1.057 | .29 | 0.005 | .95 | |
| TF | rs2370409 | 3q22.1 | −0.31 | .76 | 0.3 | .58 |
| rs12595 | 0.178 | .86 | 0.033 | .86 | ||
| rs1984630 | −0.962 | .34 | 0.158 | .69 | ||
| TNF | rs169679 | 6p22.1 | −0.386 | .69 | 0.009 | .92 |
| rs11908 | 6p21.32 | 0.747 | .45 | 1.734 | .19 | |
| ESR1 | rs10002 | 6q25.1 | −0.407 | .68 | 0.473 | .49 |
| rs718527 | 0.221 | .82 | 0.014 | .91 | ||
| UBQLN1 | rs1359168 | 9q21.32 | 1.388 | .17 | 0.019 | .89 |
| rs944947 | 0.814 | .42 | 1.204 | .27 | ||
| rs918223 | −1.547 | .12 | 0.695 | .40 | ||
| TFAM | rs1338799 | 10q21.1 | 0.1 | .92 | 0.021 | .88 |
| rs1904764 | 0.531 | .59 | 1.197 | .27 | ||
| rs1427209 | −0.371 | .71 | 0.042 | .84 | ||
| PLAU | rs2227551 | 10q22.2 | 0.012 | .99 | 1.38 | .24 |
| rs4065 | −0.255 | .79 | 0.073 | .79 | ||
| IDE | rs1329656 | 10q23.33 | −1.492 | .14 | 0.768 | .38 |
| rs1111875 | −0.75 | .45 | 0.016 | .90 | ||
| CALHM1 | rs6580 | 10q24.33 | −0.481 | .63 | 1.393 | .24 |
| rs276219 | 10q25.1 | −1.151 | .25 | 1.947 | .16 | |
| GAB2 | rs1945085 | 11q14.1 | −0.719 | .47 | 0.094 | .76 |
| rs1945465 | 0.346 | .73 | 1.419 | .23 | ||
| SORL1 | rs596437 | 11q23.3 | −1.613 | .11 | 0.552 | .46 |
| rs617847 | 2.146 | .03 | 0.017 | .90 | ||
| rs676943 | −1.103 | .27 | 1.446 | .23 | ||
| GAPDH | rs740839 | 12p13.31 | −1.878 | .06 | 0.03 | .86 |
| rs2365567 | 0.854 | .39 | 1.217 | .27 | ||
| LRP6 | rs732868 | 12p13.2 | 1.689 | .09 | 7.888 | .005 |
| rs4763797 | 0.545 | .56 | 0.228 | .63 | ||
| PSEN1 | rs7155380 | 14q24.2 | 2.568 | .01 | 0.026 | .87 |
| rs977357 | 14q24.3 | −0.149 | .88 | 0.448 | .50 | |
| ACE | rs1557720 | 17q23.2 | 0.712 | .48 | 0.906 | .34 |
| rs4353 | 17q23.3 | −1.952 | .05 | 0.004 | .95 | |
| rs1043127 | 17q23.3 | −0.101 | .92 | 0.057 | .81 | |
| APOC | rs11671074 | 19q13.31 | −0.063 | .95 | 0.017 | .90 |
| rs1603 | −1.593 | .11 | 0.722 | .40 | ||
| rs2041975 | 0.402 | .69 | 0.006 | .94 | ||
| PRNP | rs241605 | 20p13 | −0.717 | .47 | 2.335 | .13 |
| rs1535382 | −0.682 | .49 | 1.984 | .16 | ||
| rs1131382 | −1.45 | .15 | 0.197 | .66 | ||
| CST3 | rs970177 | 20p11.22 | −0.766 | .44 | 0.091 | .76 |
| rs7988 | 20p11.21 | 0.571 | .57 | 0.173 | .68 | |
| rs958075 | 20p11.21 | −1.519 | .13 | 0.098 | .75 | |
Abbreviations: FBAT, family-based association test; SNP, single-nucleotide polymorphism.
a
Each row represents the results for a single SNP within the named gene. Available SNPs within the candidate genes were examined. Modestly significant associations were found for SORL1, LRP6−1, PSEN1−1, and ACE1.