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. 2009 Apr 20;18(13):2472–2482. doi: 10.1093/hmg/ddp185

Figure 2.

Figure 2.

Limb phenotype of Fmn1Pro/Pro mice. Alizarin red stained adult wild-type and Fmn1Pro/Pro mouse fore and hindlimbs. (A) Wild-type forelimb, (B) Fmn1Pro/Pro forelimb, (C) wild-type hindlimb and (D) Fmn1Pro/Pro hindlimb. Fmn1Pro/Pro limbs possessed only four digits and a defined radius and ulna in the forelimb. The arrowhead indicates the fused posterior metatarsal bones of the Fmn1Pro/Pro hindlimb. Alizarin red stained adult (E and F) wild-type and (G and H) Fmn1Pro/Pro mouse forelimbs and hindlimbs. The arrow indicates the absence of the fibula in the Fmn1Pro/Pro hindlimb. Sectioned hematoxylin and eosin stained hindlimb autopods of (I) wild-type and (J) Fmn1Pro/Pro mice. Alcian blue and alizarin red stained neo-natal wild-type and GremΔ/+; Fmn1Pro/+ mouse fore and hindlimbs. (K) Wild-type forelimb, (L) GremΔ/+; Fmn1Pro/+ forelimb, (M) wild-type hindlimb, (N) GremΔ/+; Fmn1Pro/+ hindlimb. Abbreviations used: forelimb, F; hindlimb, H.