Table 1.
Genetic background of mice contributes to the phenotypic penetrance of the Fmn1Pro/Pro allele
| Genotype | Limb phenotype | No. of mutants/total | Kidney phenotype | No. of mutants/total |
|---|---|---|---|---|
| Fmn1Pro/+ | Normal | 0/88 (0%) | Normal | 0/88 (0%) |
| Fmn1Pro/Pro (129/SvEv) | Four digits | 90/136 (66%) | Renal aplasia | 6/136 (4.4%) |
| Fmn1Pro/Pro (FVB) | Four digits | 32/32 (100%) | Renal aplasia | 16/32 (50%) |
The table represents the number of animals examined that displayed a mutant phenotype as a percentage of the total, no. of mutants/total. Mice were examined for both a limb and kidney phenotype. The genotypes of the animals were heterozygous for Fmn1, Fmn1Pro/+, homozygous on the 129Sv/Ev background, Fmn1Pro/Pro (129Sv/Ev) or homozygous on the FVB background, Fmn1Pro/Pro (FVB).