Table 3.
Changes in tetramer frequencies to melanoma differentiation antigens
| Dose level | Antigen reactivity | Non-detectable pre- and post-treatment | Non-detectable pre-treatment/detectable post treatment | Detectable pre-treatment/ non-detectable post treatment | Detectable pre-and post treatment |
|---|---|---|---|---|---|
|
500 (n=2) |
MART-1 | 1 | 0 | 1 [0.13↓] |
0 |
| gp100 | 1 |
1 [↑ 0.16] |
0 | 0 | |
| tyrosinase | 2 | 0 | 0 | 0 | |
|
1000 (n=5) |
gp100 | 3 |
1 [↑ 0.07] |
1 [0.06↓ ] |
0 |
| MART-1 & tyrosinase | 5 | 0 | 0 | 0 | |
|
1250 (n=2) |
gp100 | 0 | 0 | 2 [0.06↓ ;0.05↓] |
0 |
| MART-1 & tyrosinase | 2 | 0 | 0 | 0 | |
|
1500 (n=3) |
MART-1 | 0 | 0 | 0 | 3 [0.11↑0.12 ; 0.14↑0.17 ; 0.13↑0.23] |
| gp100 | 0 |
2 [↑ 0.08 ;↑ 0.11] |
0 | 1 [0.08↑0.13] |
|
| tyrosinase | 0 | 0 | 0 | 3 [0.09↑0.16 ; 0.26↓0.17; 0.20↑0.29] |
|
|
1750 (n=4) |
MART-1 | 0 | 0 | 3 [ 0.08↓ ; 0.07↓ ; 0.05↓] |
1 [0.18↓0.10] |
| gp100 | 0 | 0 | 1 [ 0.06↓] |
3 [0.08↑0.11 ; 0.08↓0.07; 0.09↓0.06] |
|
| tyrosinase | 1 | 0 | 0 | 3 [0.16↓0.06; 0.07↑0.11; 0.10↑0.30] |
|
|
2000 (n=5) |
MART-1 | 0 | 0 | 0 | 5 [0.06↑0.18; 0.12↑0.14; 0.86↓0.61; 0.16↓0.12; 0.28↓0.22] |
| gp100 | 0 | 0 | 0 | 5 [0.15↑0.40; 4.70↑20.1; 0.14↑0.38; 0.11↑0.12; 0.20↑0.68] |
|
| tyrosinase | 1 |
1 [↑ 0.18] |
3 [0.06↑0.10; 0.50↑1.12; 0.44↓0.16] |