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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Nat Neurosci. 2009 Jan 25;12(2):172–181. doi: 10.1038/nn.2249

Figure 4.

Figure 4

PEST motif deletion and prenylation of PSD-95 does not affect NMDAR-triggered endocytosis of AMPARs. Representative images (a) and quantitation (b) of surface AMPAR (GluR1) staining in cells expressing GFP or PSD-95ΔPEST. Representative images (e) and quantitation (g) of NMDAR-triggered endocytosis of AMPARs in cells expressing GFP or PSD-95ΔPEST. Representative images (c) and quantitation (d) of surface AMPAR (GluR1) staining in cells expressing GFP, sh95 or sh95 and PSD-95pre. Note that the prenylated PSD-95 (PSD-95pre) rescues the decrease in AMPAR surface expression caused by sh95. Representative images (f) and quantitation (h) of NMDAR-triggered endocytosis of surface AMPARs in cells expressing GFP, sh95 or sh95 and PSD-95pre. Scale bar, 20 µm. *** indicates p < 0.001 and n.s indicates p > 0.05.