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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Nat Neurosci. 2009 Jan 25;12(2):172–181. doi: 10.1038/nn.2249

Figure 5.

Figure 5

SH3 and GK domains of PSD-95 are required for NMDAR-triggered endocytosis of AMPARs. Representative images (a) and quantitation (b) of surface AMPARs in cells expressing GFP, sh95 or sh95 and PSD-95ΔSH3GK. Note that PSD-95ΔSH3GK rescues the surface expression of AMPARs. Representative images (c) and quantitation (d) of NMDAR-triggered endocytosis of surface AMPARs in cells expressing GFP, sh95 or sh95 and PSD-95ΔSH3GK. Scale bar, 20 µm. *** indicates p < 0.001 and n.s indicates p > 0.05.