Skip to main content
. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Nat Neurosci. 2009 Jan 25;12(2):172–181. doi: 10.1038/nn.2249

Figure 7.

Figure 7

Binding of calcineurin (PP2B) to AKAP150 is necessary for the NMDAR-triggered endocytosis of AMPARs. Overexpression of AKAP150 increases the surface expression of AMPARs as shown in the representative images (a) and quantitation (b) of surface AMPARs in cells expressing GFP or AKAP150. Representative images (e) and quantitation (g) of NMDAR-triggered endocytosis of surface AMPARs in cells expressing GFP or AKAP150. Representative images (c) and quantitation (d) of surface AMPARs in cells expressing GFP or AKAPΔPP2B. Representative images (f) and quantitation (h) of NMDAR-triggered endocytosis of surface AMPARs in cells expressing GFP or AKAPΔPP2B. scale bar, 20 µm. *** indicates p < 0.001 and n.s indicates p > 0.05.