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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Nat Neurosci. 2009 Jan 25;12(2):172–181. doi: 10.1038/nn.2249

Figure 8.

Figure 8

NMDA application causes loss of PSD-95 and AKAP150 from synapses. Application of NMDA causes a decrease in the synaptic localization of endogenous PSD-95, recombinant wildtype PSD-95, PSD-95ΔSH3GK and PSD-95L460P but not prenylated PSD-95 as shown in the representative images (a) and quantitation (b) of PSD-95 puncta that co-localized with presynaptic Bassoon puncta. NMDA application also causes a loss of endogenous AKAP150, recombinant wildtype AKAP150 and AKAPΔPP2B from synapses as shown in the sample images (c) and quantitation (d). Scale bar, 10 µm. *** indicates p < 0.001 and n.s indicates p > 0.05.