Table 3.

Percentages of renal and fecal excretion of total radiolabel following single intravenous administration of [¹⁴C] dihydroartemisinin with 25% cremophore EL/0.9% saline formulation at 3 mg/kg to rats (n = 5).

Sample time (days)	Urine	Feces	Cage wash
0–0.04	4.18 ± 1.06
0.04–0.33	25.49 ± 1.98	1.52 ± 0.58
0.33–1.0	14.01 ± 5.11	29.56 ± 11.75
1–2	4.78 ± 1.30	6.14 ± 1.71
2–3	1.63 ± 0.92	1.64 ± 0.78
3–4	0.72 ± 0.19	0.78 ± 0.31
4–5	0.57 ± 0.25	0.46 ± 0.09
5–6	0.46 ± 0.37	0.15 ± 0.06
6–7	0.16 ± 0.02	0.11 ± 0.05
7–8	0.09 ± 0.04	0.04 ± 0.04
Total	52.09 ± 8.94	40.39 ± 13.22	1.88 ± 2.27
Ratio of excretion (urine/feces)	1.37 ± 0.39
Balance (% of dose)	94.36 ± 16.71
Elimination parameters
Peak height (μg/rat)	234.48 ± 33.74	292.39 ± 150.29
Peak time (days)	0.37 ± 0.06	0.67 ± 0.09
Fast elimination phase (days)	0.32 ± 0.07	0.35 ± 0.11
Slow elimination phase (days)	1.36 ± 0.25	1.29 ± 0.47

All values expressed as % of dose, mean ± SD, n = 5.