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. Author manuscript; available in PMC: 2009 Jun 10.
Published in final edited form as: Radiother Oncol. 2007 Jun 8;83(3):249–255. doi: 10.1016/j.radonc.2007.05.016

Figure 1.

Figure 1

Serial observation of tumor cell – vascular interactions during early tumor growth. Vasodilation and increased vascular tortuosity is observed within 24h following transplant of only a few tumor cells. Red arrow: an elongated 4T1GFP tumor cell (Day 2). Vascular cooption is observed as tumor cells proliferate and migrate toward existing host vasculature (Day 4). Angiogenesis is first observed when total tumor size is less than 200 μm diameter. Arrows: tumor (localized in the marked circle)-associated new microvessels (Day 8). Bar, 200 μm. Figure reconfigured from Li et al.4, with permission from the publisher.