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Summary of effects of radiation therapy on HIF-1. HIF-1: hypoxia inducible factor-1; ROS: reactive oxygen species; RNOS: reactive nitric oxygen species (RNOS); iNOS: inducible nitric oxide synthase (iNOS); ODD: oxygen-dependent degradation; PHD: prolyl hydroxylase. Not depicted in the diagram are other sources of HIF-1 control, such as hypoxia and oncogene/suppressor gene regulation.
