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Model of the catalytic and non-catalytic functions of p110β. The catalytic activity of p110β is triggered by both RTK and GPCR signaling and cooperates in Akt activation, cancer development and glucose homeostasis (left side). p110β also functions as a scaffold protein (right inset) required for the organization at the plasma membrane of clathrin coated pits or vesicles, thus controlling RTK endocytosis.
