Table I.
Metabolic measurements in Pik3cbK805R/K805R Mice
| PIK3CBWT/WT | PIK3CBK805R/K805R | P by Student t | |
|---|---|---|---|
| Triglycerides (mg/dL) | 109±11 | 71±6 | <0.05 |
| Cholesterol (mg/dL) | 66±3 | 45±2 | <0.01 |
| Free Fatty Acids (mM) | 1.5±0.1 | 1.4±0.1 | NS |
| AST (UI) | 78±16 | 63±8 | NS |
| ALT (UI) | 47±12 | 37±3 | NS |
| Plasma Albumin (g/dL) | 2.3±0.1 | 2.2±0.1 | NS |
| Leptin (ng/ml) | 0.72±0.08 | 0.69±0.09 | NS |
| Cumulative Food Intake (g food/q BW per 10 days) | 0.30±0.02 | 0.27±0.01 | NS |
| SREBF1C mRNA (% of WT) | 100 | 72±4 | <0.01 |
| PCK1 mRNA (% of WT) | 100 | 147±6 | <0.01 |
| G6PC mRNA (% of WT) | 100 | 172±1 | <0.01 |
| FBP1 mRNA (% of WT) | 100 | 134±7 | <0.01 |
AST (aspartate aminotransferase); ALT (alanine transaminase); SREBF1C (sterol regulator element-binding protein-1c); PCK1 (phosphoenolpyruvate carboxykinase-1); G6PC (glucose-6-phosphatase, catalytic subunit); FBP1 (fructose 1,6-bisphosphatase).