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. Author manuscript; available in PMC: 2009 Nov 21.
Published in final edited form as: Circ Res. 2008 Oct 9;103(11):1232–1240. doi: 10.1161/01.RES.0000338597.71702.ad

Figure 1.

Figure 1

Nuclear Nrf2 accumulation and cardiac protection by CO. CO breathing in mice induces HO-1 mRNA expression and enzyme activity in Wt heart after 24 hours (A). Cardiac Nrf2 nuclear localization by confocal microscopy after CO is enhanced at 12 hours (B), confirmed by nuclear protein Western blot (C). Cardiac Nrf2 mRNA increases 3-fold within 6 hours and remains elevated for 12 hours after CO (D). *P<0.05 compared with preexposure control (n=4). CO given at days 0 and 7 after Dox (E) prevents the decline in right and left ventricular ejection fraction at 14 days by Doppler ultrasound.