Table 3. Suppression of CD4+CD25− cell proliferation by CD4+CD25high T cells expanded in the presence of RAPAa.
% suppression (mean±SD) | |
No RAPA | 10±3 |
RAPA 1 nM | 77±6 |
RAPA 50 nM | 84±5 |
RAPA 100 nM | 96±6 |
Suppression of autologous responder cell proliferation with cells of 6 normal donors. Treg and responder cells were obtained from PBMC and cultured±RAPA as described in Materials and Methods.