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. 2009 Jun 26;5(6):e1000536. doi: 10.1371/journal.pgen.1000536

Figure 2. Rare exonic deletions (eDels) in NRXN1 and novel candidate genes alter predicted protein structures.

Figure 2

For each of BZRAP1 (a) NRXN1 (b) and MDGA2 (c) reference loci and encoded proteins (top) are contrasted against mutant loci and corresponding proteins (bottom; grey shading). Unique genomic deletions and corresponding protein truncations are highlighted in red and with black hatching, respectively. Schematized protein domains genes are as follows: BZRAP1—Src homology-3 (orange square), Fibronectin, type III (blue oval); NRXN1—Laminin G (orange hexagon), EGF-like (blue oval), 4.1 binding motif (green rectangle); MDGA2—IG-like domains (blue pentagon), MAM aka Meprin/A5-protein/PTPmu (blue oval).