Table I.

Pathogenesis of M148R and M149R in European rabbits.

Days p.i.	Clinical signs following virus infection
	Wild-type MYXV and MYXV-rev	MYXV-ΔM148R	MYXV-ΔM149R	MYXV-ΔM148RΔM149R
0	Intradermal inoculation of 5 rabbits with 5 000 PFU of virus	Intradermal inoculation of 5 rabbits with 5 000 PFU of virus	Intradermal inoculation of 5 rabbits with 5 000 PFU of virus	Intradermal inoculation of 5 rabbits with 5 000 PFU of virus
4–6	Primary lesions at inoculation sites: raised, soft, red (ca. 1 to 2 cm) (5/5)*	Primary lesions at inoculation sites: raised, soft, red (ca. <1 cm) (5/5)*	Primary lesions at inoculation sites: raised, soft , red (ca. 1 to 2 cm) (5/5)*	Primary lesions at inoculation sites: raised, soft, red (ca. 1 to 2 cm), multiple secondary lesions on ears (ca <1 cm) (5/5)*
8	Large and diffused primary myxomas, secondary infections of conjunctivas and respiratory tract, dyspnea, and multiple secondary lesions on face, ears, back and testis (5/5)*	Large and diffused primary myxomas, secondary light infections of conjunctivas (4/5), secondary lesions on ears (5/5)*	Primary myxoma resorbed, secondary infections of conjunctivas and respiratory tract, no secondary lesions (5/5)*	Myxoma resorbed (5/5)*, light infections of conjunctivas and respiratory tract (4/5)*
14	Multiple secondary lesions, turning necrotic. All rabbits sacrificed due to increased severity of the clinical signs (5/5)*	Myxomas resorbed, secondary infections of conjunctivas and respiratory tract (4/5)*	Secondary lesions on ears, secondary infections of conjunctivas and respiratory tract (5/5)*	Rabbits recovered (5/5)*
21		2 rabbits euthanized	Rabbits recovered (5/5)*

^*Number of rabbits suffering from clinical signs described / total number of rabbits infected with corresponding virus.