Table III.
Summary table to show experimental design variation and protection from clinical disease (lesions) in sheep following vaccination with FMD vaccines formulated for emergency use.
| Breed | Vaccine | Challenge | Days vaccinated before exposure |
Ref. | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 3 | 4 | 5 | 6 | 7 | 10 | 11 | 14 | ||||
| Crossbred | O1 BFS 1860a 19.8 μg/dosec Aqueousd |
Homologous indirect aerosol from 4 infectious pigs for 2 h |
0/4 | 4/4b | [36] | |||||||
| O1 BFS 1860 9.9 μg/dose Aqueous |
3/4 | |||||||||||
| Polled Dorset Horn |
O1 Lausanne 3.05 μg/dose Aqueous |
Homologous indirect aerosol from 3 infectious pigs for 2 h |
1/4 | 3/3 | 3/3 | 3/3 | 3/3 | [19] | ||||
| O1 Lausanne 3.05 μg/dose Oil |
3/3 | 3/3 | 3/3 | 3/3 | ||||||||
| Asia 1 India 8/79 2.25 μg/dose Oil |
Homologous indirect aerosol from 3 infectious pigs for 4 h |
0/3 | 3/3 | 3/3 | 3/3 | 3/3 | ||||||
| C1 Oberbayern 1.4 μg/dose Aqueous |
Homologous indirect aerosol from 3 infectious pigs for 4 h |
1/3 | 3/3 | 3/3 | 3/3 | 3/3 | ||||||
| Polled Dorset Horn |
C1 Oberbayern 1.4 μg/dose Oil |
Homologous indirect aerosol from 3 infectious pigs for 4 h |
0/3 | 3/3 | 3/3 | 3/3 | 3/3 | See footnote 2 | ||||
| Polled Dorset Horn |
O1 Lausanne 3.05 μg/dose Aqueous |
Homologous indirect aerosol from 2 infectious pigs for 4 h |
0/7 | 7/7 | [10] | |||||||
| Polled Dorset Horn |
O1 Manisa ? (18 PD50for cattle) Oil |
Semi-heterologous indirect aerosol from 3 infectious pigs for 9 h |
0/8 | 9/10 | 8/10 | [52] | ||||||
a
Vaccine serotype
b
number protected/total number in group
c
concentration of antigen/dose
d
vaccine type.