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Ventilation measured with whole-body plethysmography in B6/129 and Gaa−/−mice. Minute ventilation (mLs per minute) was measured during quiet breathing (i.e., baseline, 21% O2, balance N2), followed by a 10-min hypercapnic challenge (7% CO2, balance O2). A–C Data from B6/129 control (▾) and Gaa−/− mice (●) of different ages: 6 months (A), 12 months (B), and >21 months (C). *, Control response is different from Gaa−/− response, P < 0.01.
