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. 2009 May 20;106(23):9391–9396. doi: 10.1073/pnas.0812884106

Fig. 7.

Fig. 7.

Inhibition of caspase-3 activity results in a significant decrease in TcapQ activation following intravitreal injection of NMDA. Eyes (n = 4) were pretreated with either 25 nmol NMDA alone or with 25 nmol NMDA plus 2 mM DEVD-fmk, and subsequent injection of TcapQ. (A) Fluorescence microscopy of retinal flatmounts reveals a marked decrease in TcapQ activation in the presence of caspase-3 inhibitor (Right). (B) Bar graph shows the mean (±SEM) number of fluorescent TcapQ-labeled RGCs in retinal flatmounts from eyes treated with NMDA alone or NMDA + DEVD-fmk. Statistical significance of NMDA + DEVD-fmk compared with NMDA alone indicated by asterisks (**P < 0.001).