Table 3.
Main pharmacokinetic/pharmacodynamic parameters of moxifloxacin after an oral dose of 400 mg
| Bioavailability | 90% |
| Cmax | 3–4 mg/L |
| Tmax | 1–2 h |
| Mean half-life | 13 h |
| Binding to plasma proteins | <40% |
| Steady state volume of distribution | 2–3 L/kg |
| Renal clearance | 24–53 mL/min |
| Total body clearance | 179–246 mL/min |
| AUC | 35–45 mg.h L−1 |
| Cmax/MIC90 (pneumococcus) | 25–35 |
| AUC24h/MIC90 or AUIC (pneumococcus) | 192–400 mg.h L−1 |
Data from Stass (1999); Stass et al (2001).
Abbreviations: Cmax, maximal or peak plasma concentration; Tmax, time to Cmax;
AUC, area under the curve; AUIC, area under the inhibition curve; MIC, minimum inhibitory concentration.