Table 1.
Comparison of COPD patients without other causes of pulmonary hypertension
| Severe PH group (without additional causes of PH & mPAP ≥40 mm Hg) (N = 11) | Control group with less severe PH (mPAP ≥ 20 mm Hg) (N = 16) | p value | |
|---|---|---|---|
| FEV1 (% predicted) | 50 (44–56) | 27 (23–34) | <0.01 |
| DLCO (ml/min/mm Hg) | 4.6 (4.2–6.7) | 10.3 (8.9–12.8) | <0.01 |
| PaO2 (mm Hg) | 46 (41–53) | 56 (54–64) | <0.01 |
| PaCO2 (mm Hg) | 32 (28–37) | 47 (44–49) | <0.01 |
| RAP (mm Hg) | 7 (5–9) | 3 (1.3–4) | <0.01 |
| mPAP (mm Hg) | 48 (46–50) | 25 (22–27) | <0.01 |
| PCWP (mm Hg) | 6 (4–7) | 7 (6.5–7.5) | NS |
| CI (L/min/m2) | 2.3 (1.8–2.5) | 2.8 (2.4–3.1) | <0.01 |
| TPR (IU/m2) | 21.3 (17.6–26.6) | 9 (7.4–9.9) | <0.01 |
Adapted with permission from Chaouat A, Bugnet A, Kadaoui N, et al. 2005. Severe pulmonary hypertension and chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 172:189–94. Official Journal of the American Thoracic Society. © American Thoracic Society.
Abbreviations: FEV1, forced expiratory volume in the first second; DLCO, diffusing capacity; RAP, right atrial pressure; mPAP, mean pulmonary artery pressure; PCWP, pulmonary capillary wedge pressure; CI, cardiac index; TPR, total pulmonary resistance; IU, international units.