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. 2009 May 20;5:227–235. doi: 10.2147/ndt.s5040

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© 2009 Trachte et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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Absolute change in serotonin (5-HT) excretion when responses are segregated by change in urinary serotonin excretion as follows: no 5-hydroxytryptophan (5-HTP) dose (phase 0); inverse responses of urinary serotonin excretion to changes in 5-HTP (phase 1); no change in urinary serotonin excretion in response to changes in 5-HTP dose (phase 2); and direct correlation between changes in urinary serotonin excretion and changes in 5-HTP dose (phase 3). All values are means + SE. Values in both phases 1 and 3 were greater than phases 0 (random fluctuation) or 2 (***p < 0.0001). Phase 2 responses were less than phase 0 (***p < 0.001) and the N was 375.