Table 2.

Combined effect of PDE11A and PDE1A genes on the antidepressant response

No. of risk allele	rs1880916	rs1549870	Remitter/nonremitter	Remission rate %	RR (95% CI)	pvalue
0	GG	AG/AA	2/11	0.15	1.00	–
1	GG	GG	55/42	0.57	3.69 (1.02–13.34)	0.047
2	AG/AA	AG/AA	3/3	0.50	3.25 (0.72–14.64)	0.125
3	AG/AA	GG	22/5	0.81	5.30 (1.46–19.19)	0.011

Note: Rothman synergy index = (5.30–1)/(3.25 +3.69 − 2) ≈1.

Abbreviations: CI, confidence interval; RR, relative risk.