Table 3.

Estimated frequency for 16-locus (SNP1–16)^a haplotype in depression (MDD), control groups (CT), remitter (R), and nonremitter groups (NR)

Order	Sequenceb	Diagnosis			Antidepressant treatment			Note
		MDD (%) N = 556	CT (%) N = 642	p value	R (%) N = 164	NR (%) N = 122	p value
H1	CAGAGCACGCCAAAGC	341 (61.3)	374 (58.3)	0.288	104 (63.4)	73 (59.8)	0.541	Common
H2	CAGGATGCTAGGGCGC	27 (4.7)	26 (4.1)	0.574	7 (4.3)	6 (4.9)	0.783	MDD
H3	CAGAGCACGCGAGAAT	26 (4.7)	49 (7.6)	0.042	10 (6.1)	6 (4.9)	0.797	Common
H4	CAGAACACGCCAAAGC	18 (3.2)	0 (0)	<0.001	6 (3.7)	4 (3.3)	1.000	MDD
H5	CAGAGCACGCCGGCGC	14 (2.5)	19 (3.0)	0.598	4 (2.4)	5 (4.1)	0.503	Common
H6	CAGGATGATACGGCGC	9 (1.6)	8 (1.3)	0.631	3 (1.8)	1 (0.8)	0.639	Common
H7	GAGAGCACGCCAAAGC	8 (1.4)	15 (2.3)	0.205	0 (0)	3 (2.5)	0.077	Normal
H8	CAGAGCACGCGGGCGC	8 (1.4)	12 (1.9)	0.654	0 (0)	5 (4.1)	0.013	Common
H9	GAGAGCACGCGAGAAT	8 (1.4)	10 (1.6)	1.000	2 (1.2)	0 (0)	0.509	Common
H10	CAGAGCACGCGGGCGT	6 (1.1)	4 (0.6)	0.528	1 (0.6)	3 (2.5)	0.316	Common
H11	CCGGATGATACGGCGC	6 (1.1)	17 (2.7)	0.057	0 (0)	2 (1.6)	0.181	Normal
H12	CAGGATGATACAGAAT	5 (0.9)	0 (0)	0.021	1 (0.6)	0 (0)	1.000	MDD
H13	CAGGATGATAGGGCGC	5 (0.9)	5 (0.8)	0.759	1 (0.6)	0 (0)	1.000	Common
H14	CCGAGCACGCGAGAAT	4 (0.7)	9 (1.4)	0.280	1 (0.6)	0 (0)	1.000	Normal
H15	CAGAGCACGCCAGAAT	0 (0)	6 (0.9)	0.033	0 (0)	0 (0)	1.000	Normal
H16	CCGAGCACGCGGGCGC	0 (0)	8 (1.3)	0.009	0 (0)	0 (0)	1.000	Normal
H17	CCGGATGCTAGGGCGT	0 (0)	5 (0.8)	0.065	0 (0)	0 (0)	1.000	Common
H18	GAGAGCACGCCGGCGC	0 (0)	7 (1.1)	0.017	0 (0)	0 (0)	1.000	Normal
Total		485 (87.2)	574 (89.4)			140 (85.4)	109 (89.3)

Notes: ^aSee Table 1 for definitions of the SNP1–16, and the haplotype is from 3′ to 5′ in PDE11A;

^bThe SNPs are bold and underlined in the haplotype that is different with most common haplotype.

Abbreviations: MDD, major depressive disorder; SNP, single-nucleotide polymorphisms; PDE, phosphodiesterase.