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. 2009 Apr 8;5:163–170. doi: 10.2147/ndt.s4771

Table 4.

Estimated frequency for 16-locus (SNP1–16)a genotype in depression (MDD), control groups (CT), remitter (R), and nonremitter groups (NR)

Genotype Diagnosis
Antidepressant response
MDD (%) (N = 278) CT (%) (N = 321) R (%) (N = 82) NR (%) (N = 61)
H1/H1b 115 (41.4) 120 (37.4) 34 (41.5) 26 (42.6)
H1/H2 14 (5.0) 14 (4.4) 5 (6.1) 3 (4.9)
H1/H3 18 (6.5) 26 (8.1) 8 (9.8) 4 (6.6)
H1/H4 8 (2.9) 0 (0)** 3 (3.7) 1 (1.6)
H1/H5 10 (3.6) 13 (4.0) 3 (3.7) 4 (6.6)
H1/H6 8 (2.9) 5 (1.6) 2 (2.4) 1 (1.6)
H1/H8 4 (1.4) 7 (2.2) 0 (0) 2 (3.3)
H1/H9 5 (1.8) 6 (1.9) 2 (2.4) 0 (0)
H2/H3 4 (1.4) 4 (1.2) 1 (1.2) 2 (3.3)
H2/H4 4 (1.4) 0 (0)* 1 (1.2) 1 (1.6)

Notes: MDD vs CT:

*

p = 0.046;

**

p = 0.002;

a

See Table 1 for definitions of the SNP1–16, and the haplotype is from 3′ to 5′ in PDE11A;

b

The haplotype is named after Table 3.

Abbreviations: MDD, major depressive disorder; SNP, single-nucleotide polymorphisms; PDE, phosphodiesterase.