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. 2009 May 14;10(5):2136–2145. doi: 10.3390/ijms10052136

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 4. — Effect of RADA16-I on K562 tumor growth. We analyzed the effect of RADA16-I on K562 tumor growth by using mouse models. (A) After treatment with RADA16-I, average tumor weight in treatment group (1.51 ± 0.08 g) was markedly decreased as compared with that in control group (2.72 ± 0.50 g), data shown are Means ± SEM, P < 0.05. (B) Histological examination of tumors. Tumors were fixed with formaldehyde, and sectioned for histological examination by H & E staining. H & E staining showed that massive cell death existed in tumors treated by RADA16-I compared with the controls. These results suggested that RADA16-I could inhibit the K562 tumor growth in vivo.