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. 2009 May 14;10(5):2136–2145. doi: 10.3390/ijms10052136

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 5. — Inhibition of vascular tube-formation in vitro. We evaluated the effect of RADA16-I on the tubes formation by HUVECs in vitro. (A) HUVECs treated with control solution can migrate to form a well-arranged network of tubes within 9 h. After treated with 20 μM (B) or 40 μM (C) RADA16-I, the network-like structures were broken. Treatment with 60 μM (D) or 80 μM (E) RADA16-I completely inhibited the tube formation. These data suggested that RADA16-I could inhibit the formation of vascular tubes.