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. 2009 Feb 6;106(6):91–97. doi: 10.3238/arztebl.2009.0091

Table. Examples of biomonitoring parameters.

Selection of biomonitoring parameters (exposure markers) Matrix BGW/EKA Reference value (source) BLW/HMB-II/BAT Carcinogenesis category Units
Metals
Aluminium (U) 200 15 (b) 60 µg/g creatinine (BAT) µg/L
Lead (B) 400 (300, w<45y) 90 (70, w<45y) (a) 400 (100, w<45y) (blw), 250 (hbm-ii), cancer cat.2 µg/L
Nickel (U) EKA*1 3 (a) Cancer cat. 1 µg/L
Mercury (U) 100 1.4 (a) Cancer cat. 3B 20 µg/g creatinine (HBM-II) µg/L
Organic solvents and their metabolic products
Benzene (B) EKA*2 0.001 (b) Cancer cat. 1 mg/L
o-Cresol (parameter for toluene) (U) 3 Cancer cat. 3A mg/L
Mandelic acid/phenylglyoxylic acid(parameters for styrene) (U) 600 mg/g creatinine
Methanol (U) 30 mg/L
Methylhippuric (toluric) acid (parameter for xylene) (U) 2000 mg/L
t-t-muconic acid (parameter for benzene) (U) EKA*2 mg/L
Toluene (B) 1 0.005 (b) mg/L
Xylenes (B) 1.5 0.003 (b) mg/L
Pesticides
γ-Hexachlorcyclohexane (lindane) (B) 25 0.1 (a) Cancer cat. 4 µg/L
Hexachlorobenzene (S) 150 (BAT), µg/L
(B) 0.5 (a) Cancer cat. 4
PCB153 (B) 0.8 (a) µg/L
Pentachlorophenol (S) EKA*3 12 (a) 70 (HBM-II), Cancer cat. 2 µg/L
Other hazardous substances
Isocyanate: 4,4'-MDI, 1,5-NDI, 2,4-TDI, 2,6-TDI, 1,6-HDI, IPDI (U) 10 (for 4,4'-MDI) 4,4'-MDI: Cancer cat 4; µg/L
1,5-NDI: Cancer cat 3B;
2,4-TDI: Cancer cat 3A;
2,6-TDI: Cancer cat 3A µg/g creatinine

IBAT, BLW, HBM-II, and EKA values are only given when there is no BGW value and/or these values differ from the BGW: Reference values: m, 20-29 Y. Abbreviations: U: urine; B: whole blood;

S: serum; Source for limit values: BGW: biological limit value (14c, www.baua.de); BLW: biological guidance value; EKA: exposure equivalents for carcinogenic substances (16); reference values:

a) www.uni-duesseldorf.de/awmf/II/002-024;

b) www.IgI.bayern.de;

c) www.cdc.gov; more biomonitoring parameters: www.uke.uni-hamburg.de/Institute/Arbeitsmedizin

*1, EKA for nickel (nickel as metal oxide, carbonate or sulfide): 15 µg/L (U) is equivalent for 0.10 mg/m3 nickel (air)

*2, EKA for 0.005mg/L benzene (B) and 2 mg/L t-t-muconic acid (U) is equivalent for 1 ppb (3.3 mg/m3) benzene (air)

*3, EKA for pentachlorophenol: 17 µg/L (S) is equivalent for 0.001 mg/m3 (air)