Table 2. The treatment of psoriasis vulgaris (induction therapy).

Severity of psoriasis	Treatment		Effectiveness*1	Evidence level*1
	Agent	Administration
Mild*2	Dithranol	Local	++	2
	Corticoids (class II-IV agents)	Local	++++	1
	Vitamin D3 and its analogues	Local	+++	1
Moderate to severe	UVB	Local	+++	2
	PUVA	Local	+++ to ++++	2
	Acitretin	Oral	+	3
	Ciclosporine	Oral	++ to +++	1
	Fumarates	Oral	++	2
	Methotrexate	Preferably subcutaneous	++	3
	Efalizumab	Subcutaneous	+	1
	Etanercept	Subcutaneous	+ to ++	1
	Infliximab	Intravenous	+++ to ++++	1
	Adalimumab	Subcutaneous	+++ to ++++	(1)*3

^*1 Assessment according to S3 guidelines (14); evaluation scale: – (poor), +/–, +, ++, +++, ++++ (good).

^*2 Topical therapy is also used for moderate to severe psoriasis in combination with UV or systemic therapy.

^*3 Assessment on the basis of published studies; because this agent had not been approved when the S3 guidelines were written, it is not evaluated there.