. Author manuscript; available in PMC: 2009 Jun 11.

Published in final edited form as: Life Sci. 2008 Feb 14;82(15-16):855–861. doi: 10.1016/j.lfs.2008.01.019

Table I.

Binding to cells containing BB receptors

	NCI-H1299	Balb/3T3 with BB₂R	Balb/3T3 with BB₁R	Balb/3T3 with BRS-3

Peptide		IC₅₀, nM
BA2	6 ± 1	0.6 ± 0.1	12 ± 1	14 ± 2
Dol-LC-BA1	150 ± 18	21 ± 2	270 ± 30	370 ± 60
Dols-LD-BA1	20 ± 2	4 ± 1	190 ± 30	380 ± 40
Dols-LE-BA1	15 ± 1	18 ± 2	1120 ± 90	1420 ± 130
Hem-LA-BA1	15 ± 2	8 ± 1	130 ± 10	540 ± 50
Hem-LB-BA1	25 ± 3	5 ± 1	69 ± 9	160 ± 30

The mean value ± S.D. of 3 determinations each repeated in quadruplicate is indicated. (¹²⁵I-Tyr⁴)BB was bound to NCI-H1299 cells for 20 min at 37°C. ¹²⁵I-BA2 was bound to Balb/3T3 cells for 60 min at 25°C. The structures of the peptides are shown below:

BA1 DPhe-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH₂

BA2 DTyr-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH₂