Figure 2.

Effects of altered I_h on RMP and R_in. (A) Increased h-current density depolarizes the neuronal RMP (bringing it closer to firing threshold) but decreases the R_in (reducing the effect of inputs). Decreased h-current density hyperpolarizes the neuronal RMP (bringing it further away from firing threshold) but increases the R_in (increasing the effect of inputs). The effects on the RMP are further increased when the h-current V_1/2 is depolarized or hyperpolarized in addition to density changes. (B) Holding neurons with altered I_h at the control resting membrane potential (control MP) abolishes the depolarizing or hyperpolarizing effects on the RMP, but further accentuates the respective decrease or increase of R_in by increased or decreased h-current density.