Figure 4.

Effect of increased I_h on summation and AP firing. The effect of five small EPSPs from the RMP (A1, B1) and the common holding potential at control RMP (A2, B2) in two CA1 pyramidal neuron models (A1, A2, Poolos et al., 2002; B1, B2, Poirazi et al., 2003) with control I_h (blue) and increased I_h density with depolarized V_1/2 (red). Note that the increased I_h leads to less summation, but firing of APs is abolished when the depolarization of the RMP is eliminated by holding the cells at a common control RMP.