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. 2009 May 22;9:10. doi: 10.1186/1472-6904-9-10

Table 2.

Mean pharmacokinetic parameters after multiple intravenous epoetin doses.

Treatment AUCτ mIU/mL*h) Cmax, ss (mIU/mL) tmax (h) Ctrough (mIU/mL) t1/2 (h)
HX575 Mean 8422 2189 0.086 9.811 4.14
SD 2419 393.7 0.019 2.728 1.71
Min 4327 1203 0.083 5.565 1.90
Median 7930 2180 0.083 9.174 3.48
Max 19321 3197 0.200 18.61 8.43
GeoM 8153 2153 - 9.486 3.85
GeoCV 25.4% 19.3% - 26.2% 39.0%

Comparator Mean 9224 2262 0.083 9.446 4.74
SD 1850 422.0 0.000 2.438 2.00
Min 4977 1272 0.083 5.020 1.31
Median 9181 2210 0.083 9.161 4.45
Max 13268 3161 0.083 15.77 11.03
GeoM 9036 2222 - 9.141 4.37
GeoCV 21.1% 19.7% - 26.6% 43.5%

AUCτ = area under total concentration curve from 0–36 h at steady state; Cmax, ss = peak serum concentration at steady state; tmax = time to Cmax, ss; Ctrough = mean pre-dose trough concentration; t1/2 = terminal elimination half-life; SD = standard deviation; GeoM = geometric mean; GeoCV = coefficient of variation of GeoM. Number of subjects analysed: n = 37 (HX575) and n = 39 (comparator).