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Barrier during opening of the lid. The movement of helix α5 (residues 134 to 150) was blocked by helix α6 (residues 156 to 166) during simulation of closed BCL in toluene (B) from their starting conformation (A). The unfolding of residues 156 to 159 of helix α6 would be necessary for the complete movement of the lid (C).
